AQUAMAL QS TABS x6 GREEN

Aquamal QS comprises a fixed combination of 1 part of Artemether and 6 parts of Lumefantrine. Artemether has quick onset of action while Lumefantrine has longer duration of action. Both exerts their anti-parasitic action at the blood stage of malarial parasite, where they convert the haem (a toxic metabolite produced during haemoglobin breakdown) to nontoxic haemozoin (malaria pigment).

Lumefantrine interfaces with the polymerization process, while Artemether generates reactive metabolites as a result of interaction between its peroxide bridge & haem iron. Both components also have a secondary action involving inhibition of nucleic acid and protein synthesis within the malarial parasite. There is a synergism of independant actions of both Artemether and Lumefantrine, which has been shown to potentiate the blood schizontocidal effects. It is also effective against drug resistant strains of P. falciparum malaria.

Comprehensive in vitro studies using laboratory maintained and fresh field parasite isolates from different malaria endemic areas have shown marked synergic effect of these two components. Results of comparative clinical trials indicate that this Artemether and Lumefantrine combination also clears gametocytes more rapidly than other conventional antimalarials.